Mutation of a Single CTCF Target Site within the H19 Imprinting Control Region Leads to Loss of Igf2 Imprinting and Complex Patterns of De Novo Methylation upon Maternal Inheritance

The differentially methylated imprinting control region (ICR) region upstream of the H19 gene regulates allelic Igf2 expression by means of a methylation-sensitive chromatin insulator function. We have previously shown that maternal inheritance of mutated (three of the four) target sites for the 11-...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Pant, Vinod, Kurukuti, Sreenivasulu, Pugacheva, Elena, Shamsuddin, Shaharum, Mariano, Piero, Renkawitz, Rainer, Klenova, Elena, Lobanenkov, Victor, Ohlsson, Rolf
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2004
Schlagworte:	Gene Expression
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC381662/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15060168/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.8.3497-3504.2004
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