Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease

BACKGROUND: Monogenic gain-of-function protein aggregation diseases, including Huntington’s disease, exhibit substantial variability in age of onset, penetrance, and clinical symptoms, even between individuals with similar or identical mutations. This difference in phenotypic expression of proteotox...

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Main Authors: Gidalevitz, Tali, Wang, Ning, Deravaj, Tanuja, Alexander-Floyd, Jasmine, Morimoto, Richard I
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816611/
https://ncbi.nlm.nih.gov/pubmed/24079614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-11-100
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