Leptin Modulates Allograft Survival by Favoring a Th2 and a Regulatory Immune Profile

Leptin, an adipose-secreted hormone, links metabolism and immunity. Our aim was to determine whether leptin affects the alloimmune response. We used an allogeneic skin transplant model as a means to analyze the allograft immune response in Lep(ob/ob) and wild-type mice. Leptin deficiency results in...

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Autors principals: Moraes-Vieira, P. M. M., Bassi, E. J., Larocca, R. A., Castoldi, A., Burghos, M., Lepique, A. P., Quintana, F. J., Araujo, R. C., Basso, A. S., Strom, T. B., Câmara, N. O. S.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816358/
https://ncbi.nlm.nih.gov/pubmed/23016759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-6143.2012.04283.x
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