Saccharomyces cerevisiae Rrm3p DNA Helicase Promotes Genome Integrity by Preventing Replication Fork Stalling: Viability of rrm3 Cells Requires the Intra-S-Phase Checkpoint and Fork Restart Activities

Rrm3p is a 5′-to-3′ DNA helicase that helps replication forks traverse protein-DNA complexes. Its absence leads to increased fork stalling and breakage at over 1,000 specific sites located throughout the Saccharomyces cerevisiae genome. To understand the mechanisms that respond to and repair rrm3-de...

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Publicado en:Mol Cell Biol
Autores principales: Torres, Jorge Z., Schnakenberg, Sandra L., Zakian, Virginia A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2004
Materias:
DNA Dynamics and Chromosome Structure
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC381616/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15060144/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.8.3198-3212.2004
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