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Local chromatin structure at the ribosomal DNA causes replication fork pausing and genome instability in the absence of the S. cerevisiae DNA helicase Rrm3p

Lack of the yeast Rrm3p DNA helicase causes replication defects at multiple sites within ribosomal DNA (rDNA), includingat the replication fork barrier (RFB). These defects were unaltered in rrm3 sir2 cells. When the RFB binding Fob1p was deleted, rrm3-generated defects at the RFB were eliminated, b...

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Detalhes bibliográficos
Main Authors: Torres, Jorge Z., Bessler, Jessica B., Zakian, Virginia A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC374232/
https://ncbi.nlm.nih.gov/pubmed/15037547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1154704
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