pVHL Modification by NEDD8 Is Required for Fibronectin Matrix Assembly and Suppression of Tumor Development

Functional inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene is the cause of the familial VHL disease and most sporadic renal clear-cell carcinomas (RCC). pVHL has been shown to play a role in the destruction of hypoxia-inducible factor α (HIF-α) subunits via ubiquitin-mediated prote...

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Bibliografiske detaljer
Main Authors: Stickle, Natalie H., Chung, Jacky, Klco, Jeffery M., Hill, Richard P., Kaelin, William G., Ohh, Michael
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC381603/
https://ncbi.nlm.nih.gov/pubmed/15060148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.8.3251-3261.2004
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