Spartin Regulates Synaptic Growth and Neuronal Survival by Inhibiting BMP-Mediated Microtubule Stabilization

Troyer syndrome is a hereditary spastic paraplegia caused by human spartin (SPG20) gene mutations. We have generated a Drosophila disease model showing that Spartin functions presynaptically with endocytic adaptor Eps15 to regulate synaptic growth and function. Spartin inhibits bone morphogenetic pr...

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Detaylı Bibliyografya
Asıl Yazarlar: Nahm, Minyeop, Lee, Min-Jung, Parkinson, William, Lee, Mihye, Kim, Haeran, Kim, Yoon-Jung, Kim, Sungdae, Cho, Yi Sul, Min, Byung-Moo, Bae, Yong Chul, Broadie, Kendal, Lee, Seungbok
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3815429/
https://ncbi.nlm.nih.gov/pubmed/23439121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.12.015
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