Assessment of Mitochondrial Biogenesis and mTORC1 Signaling During Chronic Rapamycin Feeding in Male and Female Mice

Chronic inhibition of the protein synthesis regulator mTORC1 through rapamycin extends life span in mice, with longer extension in females than in males. Whether rapamycin treatment inhibits protein synthesis or whether it does so differently between sexes has not been examined. UM-HET3 mice were fe...

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Main Authors: Drake, Joshua C., Peelor, Frederick F., Biela, Laurie M., Watkins, Molly K., Miller, Richard A., Hamilton, Karyn L., Miller, Benjamin F.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
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Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814233/
https://ncbi.nlm.nih.gov/pubmed/23657975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glt047
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