Long-lived Snell dwarf mice display increased proteostatic mechanisms that are not dependent on decreased mTORC1 activity

Maintaining proteostasis is thought to be a key factor in slowed aging. In several growth-restricted models of long-life, we have shown evidence of increased proteostatic mechanisms, suggesting that proteostasis may be a shared characteristic of slowed aging. The Snell dwarf mouse is generated throu...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Drake, Joshua C, Bruns, Danielle R, Peelor, Frederick F, Biela, Laurie M, Miller, Richard A, Miller, Benjamin F, Hamilton, Karyn L
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406676/
https://ncbi.nlm.nih.gov/pubmed/25720574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12329
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