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Long-lived crowded-litter mice have an age-dependent increase in protein synthesis to DNA synthesis ratio and mTORC1 substrate phosphorylation

Increasing mouse litter size [crowded litter (CL)] presumably imposes a transient nutrient stress during suckling and extends lifespan through unknown mechanisms. Chronic calorically restricted and rapamycin-treated mice have decreased DNA synthesis and mTOR complex 1 (mTORC1) signaling but maintain...

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Библиографические подробности
Главные авторы: Drake, Joshua C., Bruns, Danielle R., Peelor, Frederick F., Biela, Laurie M., Miller, Richard A., Hamilton, Karyn L., Miller, Benjamin F.
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216950/
https://ncbi.nlm.nih.gov/pubmed/25205819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00256.2014
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