The use of self-adjuvanting nanofiber vaccines to elicit high-affinity B cell responses to peptide antigens without inflammation

Balancing immunogenicity with inflammation is a central tenet of vaccine design, especially for subunit vaccines that utilize traditional pro-inflammatory adjuvants. Here we report that by using a nanoparticulate peptide-based vaccine, immunogenicity and local inflammation could be decoupled. Self-a...

Full description

Saved in:
Bibliographic Details
Main Authors: Chen, Jianjun, Pompano, Rebecca R., Santiago, Felix W., Maillat, Lea, Sciammas, Roger, Sun, Tao, Han, Huifang, Topham, David J., Chong, Anita S., Collier, Joel H.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814015/
https://ncbi.nlm.nih.gov/pubmed/23953841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2013.07.063
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items