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Titrating T cell Epitopes within Self-Assembled Vaccines Optimizes CD4+ Helper T Cell and Antibody Outputs

Epitope content plays a critical role in determining T cell and antibody responses to vaccines, biomaterials, and protein therapeutics, but its effects are nonlinear and difficult to isolate. Here, molecular self-assembly was used to build a vaccine with precise control over epitope content, in orde...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Adv Healthc Mater
Prif Awduron: Pompano, Rebecca R., Chen, Jianjun, Verbus, Emily A., Han, Huifang, Fridman, Arthur, McNeely, Tessie, Collier, Joel H., Chong, Anita S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227912/
https://ncbi.nlm.nih.gov/pubmed/24923735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201400137
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