The use of self-adjuvanting nanofiber vaccines to elicit high-affinity B cell responses to peptide antigens without inflammation

Balancing immunogenicity with inflammation is a central tenet of vaccine design, especially for subunit vaccines that utilize traditional pro-inflammatory adjuvants. Here we report that by using a nanoparticulate peptide-based vaccine, immunogenicity and local inflammation could be decoupled. Self-a...

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Detalhes bibliográficos
Main Authors: Chen, Jianjun, Pompano, Rebecca R., Santiago, Felix W., Maillat, Lea, Sciammas, Roger, Sun, Tao, Han, Huifang, Topham, David J., Chong, Anita S., Collier, Joel H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814015/
https://ncbi.nlm.nih.gov/pubmed/23953841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2013.07.063
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