A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid

Long-chain polyunsaturated omega-3 fatty acids such as docosahexaenoic acid (DHA) at nanomolar concentrations reversibly activate human large-conductance Ca(2+)- and voltage-gated K(+) (Slo1 BK) channels containing auxiliary β1 or β4 subunits in cell-free patches. Here we examined the action of DHA...

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Hlavní autoři: Hoshi, Toshinori, Xu, Rong, Hou, Shangwei, Heinemann, Stefan H., Tian, Yutao
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2013
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3813383/
https://ncbi.nlm.nih.gov/pubmed/24127525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201311061
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