T Cell Receptor “Inside-Out” Pathway via Signaling Module SKAP1-RapL Regulates T Cell Motility and Interactions in Lymph Nodes

Although essential for T cell function, the identity of the T cell receptor “inside-out” pathway for lymphocyte function-associated antigen 1 (LFA-1) adhesion has proved elusive. Here, we define the “inside-out” pathway mediated by N-terminal SKAP1 (SKAP-55) domain binding to the C-terminal SARAH do...

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Autores principales: Raab, Monika, Wang, Hongyan, Lu, Yuning, Smith, Xin, Wu, Zhonglin, Strebhardt, Klaus, Ladbury, John E., Rudd, Christopher E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812847/
https://ncbi.nlm.nih.gov/pubmed/20346707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.03.007
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