SKAP1 Protein PH Domain Determines RapL Membrane Localization and Rap1 Protein Complex Formation for T Cell Receptor (TCR) Activation of LFA-1

Although essential for T cell function, the identity of the T cell receptor (TCR) “inside-out” pathway for the activation of lymphocyte function-associated antigen 1 (LFA-1) is unclear. SKAP1 (SKAP-55) is the upstream regulator needed for TCR-induced RapL-Rap1 complex formation and LFA-1 activation....

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Bibliographic Details
Main Authors: Raab, Monika, Smith, Xin, Matthess, Yves, Strebhardt, Klaus, Rudd, Christopher E.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191007/
https://ncbi.nlm.nih.gov/pubmed/21669874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.222661
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