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Osteoblast-targeted Suppression of PPARγ Increases Osteogenesis through Activation of mTOR Signaling

Nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is an essential transcription factor for adipocyte differentiation. In mesenchymal stem cells, PPARγ has been assumed to play a negative role in osteoblastic differentiation, by working in an adipogenesis dependent manner, due...

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Main Authors: Sun, H., Kim, J.K., Mortensen, R.M., Mutyaba, P.L., Hankenson, K.D., Krebsbach, P.H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812401/
https://ncbi.nlm.nih.gov/pubmed/23766271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1455
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