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Spermine oxidase is a regulator of macrophage host response to Helicobacter pylori: enhancement of antimicrobial nitric oxide generation by depletion of spermine

The gastric pathogen Helicobacter pylori causes peptic ulcer disease and gastric cancer. We have reported that in H. pylori-activated macrophages, nitric oxide (NO) derived from inducible NO synthase (iNOS) can kill the bacterium, iNOS protein expression is dependent on uptake of its substrate L-arg...

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Detalhes bibliográficos
Main Authors: Chaturvedi, Rupesh, Asim, Mohammad, Barry, Daniel P., Frye, Jeanetta W., Casero, Robert A., Wilson, Keith T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812355/
https://ncbi.nlm.nih.gov/pubmed/23820617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-013-1531-z
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