Spermine Oxidase Mediates the Gastric Cancer Risk Associated With Helicobacter pylori CagA

BACKGROUND & AIMS: Helicobacter pylori-induced gastric carcinogenesis has been linked to the microbial oncoprotein CagA. Spermine oxidase (SMO) metabolizes the polyamine spermine into spermidine and generates H(2)O(2) that causes apoptosis and DNA damage. We determined if pathogenic effects of C...

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Huvudupphovsmän: Chaturvedi, Rupesh, Asim, Mohammad, Romero-Gallo, Judith, Barry, Daniel P., Hoge, Svea, de Sablet, Thibaut, Delgado, Alberto G., Wroblewski, Lydia E., Piazuelo, M. Blanca, Yan, Fang, Israel, Dawn A., Casero, Robert A., Correa, Pelayo, Gobert, Alain P., Polk, D. Brent, Peek, Richard M., Wilson, Keith T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202654/
https://ncbi.nlm.nih.gov/pubmed/21839041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.07.045
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