Bortezomib Resistance Can Be Reversed by Induced Expression of Plasma Cell Maturation Markers in a Mouse In Vitro Model of Multiple Myeloma

Multiple myeloma (MM), the second most common hematopoietic malignancy, remains an incurable plasma cell (PC) neoplasm. While the proteasome inhibitor, bortezomib (Bz) has increased patient survival, resistance represents a major treatment obstacle as most patients ultimately relapse becoming refrac...

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Main Authors: Stessman, Holly A. F., Mansoor, Aatif, Zhan, Fenghuang, Linden, Michael A., Van Ness, Brian, Baughn, Linda B.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812176/
https://ncbi.nlm.nih.gov/pubmed/24204892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077608
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