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Adjusting for unknown bias in non-inferiority clinical trials

Evaluation of non-inferiority is based on ruling out a threshold for what would constitute unacceptable loss of efficacy of an experimental treatment relative to an active comparator “Standard”. This threshold, the “non-inferiority margin”, is often based on preservation of a percentage of Standard’...

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Detalhes bibliográficos
Main Authors: Odem-Davis, Katherine, Fleming, Thomas R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811957/
https://ncbi.nlm.nih.gov/pubmed/24187607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19466315.2013.795910
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