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A simulation study evaluating bio-creep risk in serial non-inferiority clinical trials for preservation of effect
In non-inferiority trials, acceptable efficacy of an experimental treatment is established by ruling out some defined level of reduced effect relative to an effective active control standard. Serial use of non-inferiority trials may lead to newly approved therapies that provide meaningfully reduced...
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| Publicado no: | Stat Biopharm Res |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4454354/ https://ncbi.nlm.nih.gov/pubmed/26052374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19466315.2014.1002627 |
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