Characterization of Binding of Raltegravir to Plasma Proteins

The objective of this study was to characterize raltegravir (RAL) binding to albumin and alpha-1-acid glycoprotein (AAG). Unbound and bound RAL were separated by ultrafiltration. The association constant (K(a)) was estimated by a graphical method. In HIV-infected patients, the average plasma protein...

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Библиографические подробности
Главные авторы: Barau, Caroline, Furlan, Valérie, Yazdanpanah, Yazdan, Fagard, Catherine, Molina, Jean-Michel, Taburet, Anne-Marie, Barrail-Tran, Aurélie
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2013
Предметы:
Antiviral Agents
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811458/
https://ncbi.nlm.nih.gov/pubmed/23856784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00625-13
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