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Characterization of Binding of Raltegravir to Plasma Proteins
The objective of this study was to characterize raltegravir (RAL) binding to albumin and alpha-1-acid glycoprotein (AAG). Unbound and bound RAL were separated by ultrafiltration. The association constant (K(a)) was estimated by a graphical method. In HIV-infected patients, the average plasma protein...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3811458/ https://ncbi.nlm.nih.gov/pubmed/23856784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00625-13 |
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