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Characteristics of Dolutegravir and Bictegravir Plasma Protein Binding: a First Approach for the Study of Pharmacologic Sanctuaries

This study aimed to characterize in vitro dolutegravir (DTG) and bictegravir (BIC) binding. They had a preferential binding to human serum albumin (HSA) with two classes of albumin sites. Human alpha-1-acid glycoprotein (HAAG) binding of DTG and BIC showed an atypical nonlinear binding. The low-affi...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Gelé, Thibaut, Gouget, Hélène, Furlan, Valérie, Becker, Pierre-Hadrien, Taburet, Anne-Marie, Lambotte, Olivier, Barrail-Tran, Aurélie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577134/
https://ncbi.nlm.nih.gov/pubmed/32868324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00895-20
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