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Mechanism of Action of T-705 Ribosyl Triphosphate against Influenza Virus RNA Polymerase
T-705 (favipiravir; 6-fluoro-3-hydroxy-2-pyrazinecarboxamide) selectively and strongly inhibits replication of the influenza virus in vitro and in vivo. T-705 has been shown to be converted to T-705-4-ribofuranosyl-5-triphosphate (T-705RTP) by intracellular enzymes and then functions as a nucleotide...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Microbiology
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3811313/ https://ncbi.nlm.nih.gov/pubmed/23917318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00649-13 |
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