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Effect of a High-Calorie, High-Fat Meal on the Bioavailability and Pharmacokinetics of PA-824 in Healthy Adult Subjects

PA-824 is a novel nitroimidazo-oxazine being developed as an antituberculosis agent. Two randomized studies evaluated the pharmacokinetics and safety of a single oral dose of PA-824 administered to healthy adult subjects 30 min after a high-calorie, high-fat meal (fed state) versus after a minimum 1...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Winter, Helen, Ginsberg, Ann, Egizi, Erica, Erondu, Ngozi, Whitney, Karl, Pauli, Elliott, Everitt, Daniel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811266/
https://ncbi.nlm.nih.gov/pubmed/23979737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00798-13
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