Early Bactericidal Activity and Pharmacokinetics of PA-824 in Smear-Positive Tuberculosis Patients

PA-824 is a novel nitroimidazo-oxazine being evaluated for its potential to improve tuberculosis (TB) therapy. This randomized study evaluated safety, tolerability, pharmacokinetics, and extended early bactericidal activity of PA-824 in drug-sensitive, sputum smear-positive, adult pulmonary tubercul...

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Detalhes bibliográficos
Main Authors: Diacon, Andreas H., Dawson, Rodney, Hanekom, Madeleine, Narunsky, Kim, Maritz, Stefan J., Venter, Amour, Donald, Peter R., van Niekerk, Christo, Whitney, Karl, Rouse, Doris J., Laurenzi, Martino W., Ginsberg, Ann M., Spigelman, Melvin K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916303/
https://ncbi.nlm.nih.gov/pubmed/20498324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01354-09
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