Early Bactericidal Activity and Pharmacokinetics of PA-824 in Smear-Positive Tuberculosis Patients

PA-824 is a novel nitroimidazo-oxazine being evaluated for its potential to improve tuberculosis (TB) therapy. This randomized study evaluated safety, tolerability, pharmacokinetics, and extended early bactericidal activity of PA-824 in drug-sensitive, sputum smear-positive, adult pulmonary tubercul...

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Hlavní autoři: Diacon, Andreas H., Dawson, Rodney, Hanekom, Madeleine, Narunsky, Kim, Maritz, Stefan J., Venter, Amour, Donald, Peter R., van Niekerk, Christo, Whitney, Karl, Rouse, Doris J., Laurenzi, Martino W., Ginsberg, Ann M., Spigelman, Melvin K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916303/
https://ncbi.nlm.nih.gov/pubmed/20498324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01354-09
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