Evaluation of Pharmacokinetic Interaction between PA-824 and Midazolam in Healthy Adult Subjects

This study assessed the safety, tolerability, and pharmacokinetic interaction between PA-824, a novel antitubercular nitroimidazo-oxazine, and midazolam, a CYP3A4 substrate, in 14 healthy adult male and female subjects. The study followed up on observations in vitro that PA-824 caused weak and time-...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Winter, Helen, Egizi, Erica, Erondu, Ngozi, Ginsberg, Ann, Rouse, Doris J., Severynse-Stevens, Diana, Pauli, Elliott, Everitt, Daniel
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
Soggetti:
Clinical Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719768/
https://ncbi.nlm.nih.gov/pubmed/23689718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02632-12
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi