Evaluation of the Pharmacokinetic Interaction between Repeated Doses of Rifapentine or Rifampin and a Single Dose of Bedaquiline in Healthy Adult Subjects

This study assessed the effects of rifapentine or rifampin on the pharmacokinetics of a single dose of bedaquiline and its M2 metabolite in healthy subjects using a two-period single-sequence design. In period 1, subjects received a single dose of bedaquiline (400 mg), followed by a 28-day washout....

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Winter, Helen, Egizi, Erica, Murray, Stephen, Erondu, Ngozi, Ginsberg, Ann, Rouse, Doris J., Severynse-Stevens, Diana, Pauli, Elliott
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335826/
https://ncbi.nlm.nih.gov/pubmed/25512422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04171-14
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