Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality

Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, play an important role in the maintenance of peripheral tolerance. We explored the role of PD-1 ligands in regulating graft-versus-host disease (GVHD). Both PD-L1 and PD-L2 expression were upregulated in the spleen, liver, colon, and ileum...

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Detalhes bibliográficos
Main Authors: Saha, Asim, Aoyama, Kazutoshi, Taylor, Patricia A., Koehn, Brent H., Veenstra, Rachelle G., Panoskaltsis-Mortari, Angela, Munn, David H., Murphy, William J., Azuma, Miyuki, Yagita, Hideo, Fife, Brian T., Sayegh, Mohammed H., Najafian, Nader, Socie, Gerard, Ahmed, Rafi, Freeman, Gordon J., Sharpe, Arlene H., Blazar, Bruce R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811178/
https://ncbi.nlm.nih.gov/pubmed/24030385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-05-500801
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