Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality

Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, play an important role in the maintenance of peripheral tolerance. We explored the role of PD-1 ligands in regulating graft-versus-host disease (GVHD). Both PD-L1 and PD-L2 expression were upregulated in the spleen, liver, colon, and ileum...

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Bibliographic Details
Main Authors: Saha, Asim, Aoyama, Kazutoshi, Taylor, Patricia A., Koehn, Brent H., Veenstra, Rachelle G., Panoskaltsis-Mortari, Angela, Munn, David H., Murphy, William J., Azuma, Miyuki, Yagita, Hideo, Fife, Brian T., Sayegh, Mohammed H., Najafian, Nader, Socie, Gerard, Ahmed, Rafi, Freeman, Gordon J., Sharpe, Arlene H., Blazar, Bruce R.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2013
Subjects:
Transplantation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811178/
https://ncbi.nlm.nih.gov/pubmed/24030385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-05-500801
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