Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality

Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, play an important role in the maintenance of peripheral tolerance. We explored the role of PD-1 ligands in regulating graft-versus-host disease (GVHD). Both PD-L1 and PD-L2 expression were upregulated in the spleen, liver, colon, and ileum...

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Main Authors: Saha, Asim, Aoyama, Kazutoshi, Taylor, Patricia A., Koehn, Brent H., Veenstra, Rachelle G., Panoskaltsis-Mortari, Angela, Munn, David H., Murphy, William J., Azuma, Miyuki, Yagita, Hideo, Fife, Brian T., Sayegh, Mohammed H., Najafian, Nader, Socie, Gerard, Ahmed, Rafi, Freeman, Gordon J., Sharpe, Arlene H., Blazar, Bruce R.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2013
主題:
Transplantation
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811178/
https://ncbi.nlm.nih.gov/pubmed/24030385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-05-500801
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