Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration

Graft-versus-host disease (GVHD) is a critical complication after allogeneic bone marrow transplantation. During GVHD, donor T cells are activated by host antigen-presenting cells and differentiate into T-effector cells (Teffs) that migrate to GVHD target organs. However, local environmental factors...

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Hlavní autoři: Aoyama, Kazutoshi, Saha, Asim, Tolar, Jakub, Riddle, Megan J., Veenstra, Rachelle G., Taylor, Patricia A., Blomhoff, Rune, Panoskaltsis-Mortari, Angela, Klebanoff, Christopher A., Socié, Gérard, Munn, David H., Murphy, William J., Serody, Jonathan S., Fulton, LeShara M., Teshima, Takanori, Chandraratna, Roshantha A., Dmitrovsky, Ethan, Guo, Yanxia, Noelle, Randolph J., Blazar, Bruce R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2013
Témata:
Transplantation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778553/
https://ncbi.nlm.nih.gov/pubmed/23814022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-11-470252
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