Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality

Programmed death ligand-1 (PD-L1) interaction with PD-1 induces T cell exhaustion and is a therapeutic target to enhance immune responses against cancer and chronic infections. In murine bone marrow transplant models, PD-L1 expression on host target tissues reduces the incidence of graft-versus-host...

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Bibliografiska uppgifter
I publikationen:J Clin Invest
Huvudupphovsmän: Saha, Asim, O’Connor, Roddy S., Thangavelu, Govindarajan, Lovitch, Scott B., Dandamudi, Durga Bhavani, Wilson, Caleph B., Vincent, Benjamin G., Tkachev, Victor, Pawlicki, Jan M., Furlan, Scott N., Kean, Leslie S., Aoyama, Kazutoshi, Taylor, Patricia A., Panoskaltsis-Mortari, Angela, Foncea, Rocio, Ranganathan, Parvathi, Devine, Steven M., Burrill, Joel S., Guo, Lili, Sacristan, Catarina, Snyder, Nathaniel W., Blair, Ian A., Milone, Michael C., Dustin, Michael L., Riley, James L., Bernlohr, David A., Murphy, William J., Fife, Brian T., Munn, David H., Miller, Jeffrey S., Serody, Jonathan S., Freeman, Gordon J., Sharpe, Arlene H., Turka, Laurence A., Blazar, Bruce R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922691/
https://ncbi.nlm.nih.gov/pubmed/27294527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85796
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