Preformed antibody, not primed T cells, is the initial and major barrier to bone marrow engraftment in allosensitized recipients

Multiply-transfused individuals are at higher risk for BM rejection. We show that whereas allosensitization resulted in the priming of both cellular and humoral immunity, preformed antibody was the major barrier to engraftment. The generation of cross-reactive alloantibody led to rejection of BM of...

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Main Authors: Taylor, Patricia A., Ehrhardt, Michael J., Roforth, Matthew M., Swedin, Jessica M., Panoskaltsis-Mortari, Angela, Serody, Jonathan S., Blazar, Bruce R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2007
Fag:
Transplantation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1785137/
https://ncbi.nlm.nih.gov/pubmed/17018854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-05-022772
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