TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection

Cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs) are synthetic ODNs with unmethylated DNA sequences that mimic viral and bacterial DNA and protect against infectious agents and tumor challenge. We show that CpG ODNs markedly accelerated graft-versus-host disease (GVHD) lethality by...

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Hauptverfasser: Taylor, Patricia A., Ehrhardt, Michael J., Lees, Christopher J., Panoskaltsis-Mortari, Angela, Krieg, Arthur M., Sharpe, Arlene H., Murphy, William J., Serody, Jonathan S., Hemmi, Hiroaki, Akira, Shizuo, Levy, Robert B., Blazar, Bruce R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2008
Schlagworte:
Transplantation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2569186/
https://ncbi.nlm.nih.gov/pubmed/18614760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-09-113670
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