TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection

Cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs) are synthetic ODNs with unmethylated DNA sequences that mimic viral and bacterial DNA and protect against infectious agents and tumor challenge. We show that CpG ODNs markedly accelerated graft-versus-host disease (GVHD) lethality by...

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Autores principales: Taylor, Patricia A., Ehrhardt, Michael J., Lees, Christopher J., Panoskaltsis-Mortari, Angela, Krieg, Arthur M., Sharpe, Arlene H., Murphy, William J., Serody, Jonathan S., Hemmi, Hiroaki, Akira, Shizuo, Levy, Robert B., Blazar, Bruce R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2008
Materias:
Transplantation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2569186/
https://ncbi.nlm.nih.gov/pubmed/18614760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-09-113670
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