A Critical Role for the TLR4/TRIF Pathway in Allogeneic Hematopoietic Cell Rejection by Innate Immune Cells

We show for the first time that signaling through the TLR4/TRIF pathway plays a critical role in allogeneic bone marrow cell (BMC) rejection. This appears to be unique to BMC as organ allografts are rejected mainly via MyD88 signaling. Using T or T/B cell-deficient mice, we found that BMC alloreject...

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Autori principali: Xu, Hong, Yan, Jun, Zhu, Ziqiang, Hussain, Lala-Rukh, Huang, Yiming, Ding, Chuanlin, Bozulic, Larry D., Wen, Yujie, Ildstad, Suzanne T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3720759/
https://ncbi.nlm.nih.gov/pubmed/23146386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3727/096368912X658881
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