A phase I/II trial and pharmacokinetic study of ixabepilone in adult patients with recurrent high-grade gliomas

Ixabepilone is an epothilone, a novel class of non-taxane microtubule stabilizing agents. A phase I/II and pharmacokinetic trial of ixabepilone was conducted in patients with recurrent high-grade gliomas. Adult patients received ixabepilone as a 1-h infusion daily for 5 days every 3 weeks. A modifie...

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Main Authors: Peereboom, David M., Supko, Jeffrey G., Carson, Kathryn A., Batchelor, Tracy, Phuphanich, Surasak, Lesser, Glenn, Mikkelson, Tom, Fisher, Joy, Desideri, Serena, He, Xiaoying, Grossman, Stuart A.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811044/
https://ncbi.nlm.nih.gov/pubmed/20449631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-010-0190-0
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