Phase I and pharmacokinetic study of karenitecin in patients with recurrent malignant gliomas

Karenitecin is a highly lipophilic camptothecin analogue with a lactone ring that is relatively resistant to inactivating hydrolysis under physiologic conditions. This phase I clinical trial was conducted to determine the maximum tolerated dose (MTD) of karenitecin in adults with recurrent malignant...

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Main Authors: Grossman, Stuart A., Carson, Kathryn A., Phuphanich, Surasak, Batchelor, Tracy, Peereboom, David, Nabors, L. Burt, Lesser, Glenn, Hausheer, Fredrick, Supko, Jeffrey G.
Formato: Artigo
Idioma:Inglês
Publicado: Duke University Press 2008
Assuntos:
Clinical Investigations
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666235/
https://ncbi.nlm.nih.gov/pubmed/18577560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2008-030
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