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Phase I and pharmacokinetic study of karenitecin in patients with recurrent malignant gliomas
Karenitecin is a highly lipophilic camptothecin analogue with a lactone ring that is relatively resistant to inactivating hydrolysis under physiologic conditions. This phase I clinical trial was conducted to determine the maximum tolerated dose (MTD) of karenitecin in adults with recurrent malignant...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Duke University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2666235/ https://ncbi.nlm.nih.gov/pubmed/18577560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2008-030 |
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