Effect of phenytoin on celecoxib pharmacokinetics in patients with glioblastoma

Cyclooxygenase-2 (COX-2) expression has been linked to the prognosis, angiogenesis, and radiation sensitivity of many malignancies. Celecoxib, a selective COX-2 inhibitor, is predominantly eliminated by hepatic metabolism. This study was conducted to determine the effects of hepatic enzyme-inducing...

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Hlavní autoři: Grossman, Stuart A., Olson, Jeffrey, Batchelor, Tracy, Peereboom, David, Lesser, Glenn, Desideri, Serena, Ye, Xiaobu, Hammour, Tarek, Supko, Jeffrey G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Duke University Press 2008
Témata:
Clinical Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613821/
https://ncbi.nlm.nih.gov/pubmed/18287342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2007-055
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