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Threading polyintercalators with extremely slow dissociation rates and extended DNA binding sites

The development of small molecules that bind DNA sequence specifically has the potential to modulate gene expression in a general way. One mode of DNA binding is intercalation, or the insertion of molecules between DNA base pairs. We have developed a modular polyintercalation system in which interca...

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Autores principales: Smith, Amy Rhoden, Iverson, Brent L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811032/
https://ncbi.nlm.nih.gov/pubmed/23919778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4057344
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