Exchange protein activated by cAMP (Epac) induces vascular relaxation by activating Ca(2+)-sensitive K(+) channels in rat mesenteric artery

Vasodilator-induced elevation of intracellular cyclic AMP (cAMP) is a central mechanism governing arterial relaxation but is incompletely understood due to the diversity of cAMP effectors. Here we investigate the role of the novel cAMP effector exchange protein directly activated by cAMP (Epac) in m...

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Main Authors: Roberts, Owain Llŷr, Kamishima, Tomoko, Barrett-Jolley, Richard, Quayle, John M, Dart, Caroline
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2013
Assuntos:
Cardiovascular
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3810813/
https://ncbi.nlm.nih.gov/pubmed/23959673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.262006
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