Overcoming intrinsic multi-drug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells

SUMMARY: Despite success with BRAFV600E–inhibitors, therapeutic responses in patients with metastatic melanoma are short-lived because of the acquisition of drug resistance. We identified a mechanism of intrinsic multi-drug resistance based on the survival of a tumor cell subpopulation. Treatment wi...

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Detalhes bibliográficos
Main Authors: Roesch, Alexander, Vultur, Adina, Bogeski, Ivan, Wang, Huan, Zimmermann, Katharina M., Speicher, David, Körbel, Christina, Laschke, Matthias W., Gimotty, Phyllis A., Philipp, Stephan E., Krause, Elmar, Pätzold, Sylvie, Villanueva, Jessie, Krepler, Clemens, Fukunaga-Kalabis, Mizuho, Hoth, Markus, Bastian, Boris, Vogt, Thomas, Herlyn, Meenhard
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3810180/
https://ncbi.nlm.nih.gov/pubmed/23764003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.05.003
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