A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth

Melanomas are highly heterogeneous tumors, but the biological significance of their different subpopulations is not clear. Using the H3K4 demethylase JARID1B (KDM5B/PLU-1/RBP2-H1) as a biomarker, we have characterized a small subpopulation of slow-cycling melanoma cells that cycle with doubling time...

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Detalhes bibliográficos
Main Authors: Roesch, Alexander, Fukunaga-Kalabis, Mizuho, Schmidt, Elizabeth C., Zabierowski, Susan E., Brafford, Patricia A., Vultur, Adina, Basu, Devraj, Gimotty, Phyllis, Vogt, Thomas, Herlyn, Meenhard
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882693/
https://ncbi.nlm.nih.gov/pubmed/20478252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.04.020
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