A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth

Melanomas are highly heterogeneous tumors, but the biological significance of their different subpopulations is not clear. Using the H3K4 demethylase JARID1B (KDM5B/PLU-1/RBP2-H1) as a biomarker, we have characterized a small subpopulation of slow-cycling melanoma cells that cycle with doubling time...

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Autori principali: Roesch, Alexander, Fukunaga-Kalabis, Mizuho, Schmidt, Elizabeth C., Zabierowski, Susan E., Brafford, Patricia A., Vultur, Adina, Basu, Devraj, Gimotty, Phyllis, Vogt, Thomas, Herlyn, Meenhard
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882693/
https://ncbi.nlm.nih.gov/pubmed/20478252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.04.020
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