Obesity-Mediated Autophagy Insufficiency Exacerbates Proteinuria-induced Tubulointerstitial Lesions

Obesity is an independent risk factor for renal dysfunction in patients with CKDs, including diabetic nephropathy, but the mechanism underlying this connection remains unclear. Autophagy is an intracellular degradation system that maintains intracellular homeostasis by removing damaged proteins and...

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Detalhes bibliográficos
Main Authors: Yamahara, Kosuke, Kume, Shinji, Koya, Daisuke, Tanaka, Yuki, Morita, Yoshikata, Chin-Kanasaki, Masami, Araki, Hisazumi, Isshiki, Keiji, Araki, Shin-ichi, Haneda, Masakazu, Matsusaka, Taiji, Kashiwagi, Atsunori, Maegawa, Hiroshi, Uzu, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2013
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3810079/
https://ncbi.nlm.nih.gov/pubmed/24092929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012111080
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