Obesity-Mediated Autophagy Insufficiency Exacerbates Proteinuria-induced Tubulointerstitial Lesions

Obesity is an independent risk factor for renal dysfunction in patients with CKDs, including diabetic nephropathy, but the mechanism underlying this connection remains unclear. Autophagy is an intracellular degradation system that maintains intracellular homeostasis by removing damaged proteins and...

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Hlavní autoři: Yamahara, Kosuke, Kume, Shinji, Koya, Daisuke, Tanaka, Yuki, Morita, Yoshikata, Chin-Kanasaki, Masami, Araki, Hisazumi, Isshiki, Keiji, Araki, Shin-ichi, Haneda, Masakazu, Matsusaka, Taiji, Kashiwagi, Atsunori, Maegawa, Hiroshi, Uzu, Takashi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2013
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3810079/
https://ncbi.nlm.nih.gov/pubmed/24092929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012111080
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