Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

Mitochondrial oxidative damage is a basic mechanism of aging, and multiple studies demonstrate that this process is attenuated by calorie restriction (CR). However, the molecular mechanism that underlies the beneficial effect of CR on mitochondrial dysfunction is unclear. Here, we investigated in mi...

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Detaylı Bibliyografya
Asıl Yazarlar: Kume, Shinji, Uzu, Takashi, Horiike, Kihachiro, Chin-Kanasaki, Masami, Isshiki, Keiji, Araki, Shin-ichi, Sugimoto, Toshiro, Haneda, Masakazu, Kashiwagi, Atsunori, Koya, Daisuke
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2010
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846062/
https://ncbi.nlm.nih.gov/pubmed/20335657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41376
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