Leptin regulation of Hsp60 impacts hypothalamic insulin signaling

Type 2 diabetes is characterized by insulin resistance and mitochondrial dysfunction in classical target tissues such as muscle, fat, and liver. Using a murine model of type 2 diabetes, we show that there is hypothalamic insulin resistance and mitochondrial dysfunction due to downregulation of the m...

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Detaylı Bibliyografya
Asıl Yazarlar: Kleinridders, André, Lauritzen, Hans P.M.M., Ussar, Siegfried, Christensen, Jane H., Mori, Marcelo A., Bross, Peter, Kahn, C. Ronald
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3809782/
https://ncbi.nlm.nih.gov/pubmed/24084737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67615
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