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Leptin regulation of Hsp60 impacts hypothalamic insulin signaling
Type 2 diabetes is characterized by insulin resistance and mitochondrial dysfunction in classical target tissues such as muscle, fat, and liver. Using a murine model of type 2 diabetes, we show that there is hypothalamic insulin resistance and mitochondrial dysfunction due to downregulation of the m...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3809782/ https://ncbi.nlm.nih.gov/pubmed/24084737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67615 |
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