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Glypican-4 Enhances Insulin Signaling via Interaction With the Insulin Receptor and Serves as a Novel Adipokine

Obesity, especially visceral obesity, is associated with insulin resistance and metabolic syndrome. We previously identified the cell surface proteoglycan glypican-4 as differentially expressed in subcutaneous versus visceral white fat depots. Here we show that glypican-4 is released from cells and...

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Autors principals: Ussar, Siegfried, Bezy, Olivier, Blüher, Matthias, Kahn, C. Ronald
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425403/
https://ncbi.nlm.nih.gov/pubmed/22751693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1395
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