Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression

RAS is the most frequently mutated oncogene in human cancers. Despite decades of effort, anti-RAS therapies have remained elusive. Isoprenylcysteine carboxylmethyltransferase (ICMT) methylates RAS and other CaaX-containing proteins, but its potential as a target for cancer therapy has not been fully...

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Main Authors: Court, Helen, Amoyel, Marc, Hackman, Michael, Lee, Kyoung Eun, Xu, Ruliang, Miller, George, Bar-Sagi, Dafna, Bach, Erika A., Bergö, Martin O., Philips, Mark R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3809775/
https://ncbi.nlm.nih.gov/pubmed/24216479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65764
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